反覆性流產的定義(Definition of RPL)

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不同的國際組織對於反覆性流產(recurrent pregnancy loss)的定義有所差異,可以分成美國、歐洲、英國等國家,大多數定義都是要超過兩次第一孕期內的流產,美國生殖醫學學會(American Society for Reproductive Medicine, ASRM)的定義需要用超音波或組織學確認多次流產才能符合設定,歐洲生殖醫學會(European Society of Human Reproduction and Embryology, ESHRE)不論是否連續只要兩次就可以診斷為反覆性流產,而英國的皇家婦產科學院(Royal College of Obstetricians and Gynaecologists, RCOG)則規定要流產三次以上才能符合,因此在閱讀各家指引的時候,需要特別注意每個指引中對於名詞定義的微妙差異,才能妥當使用。


引用資料:

Cavalcante MB, et al. 2025 American Society for Reproductive Immunology Guidelines for the Treatment of Recurrent Pregnancy Losses: Practice Recommendations From the ASRI Clinical Reproductive Immunology Fellowship. Am J Reprod Immunol. 2025 Jun;93(6):e70099.

Regan L, et al. Recurrent MiscarriageGreen-top Guideline No. 17. BJOG. 2023 Nov;130(12):e9-e39.

Turesheva A, etal. Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box. J Clin Med. 2023 Jun 15;12(12):4074.

Bender Atik R, et al. ESHRE guideline: recurrent pregnancy loss: an update in 2022. Hum Reprod Open. 2023 Mar 2;2023(1):hoad002.

van Dijk MM, et al. Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis. Hum Reprod Update. 2020 Apr 15;26(3):356-367.





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